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13 / 2021-09-08 21:09:33
Integrative analysis of specific subtypes defined by tumor immune microenvironment in hepatocellular carcinoma
hepatocellular carcinoma,immune microenvironment,immune subtypes,immune risk model
Plenary track
Draft Rejected
永康 王 / 安徽中医药大学
红星 阚 / 安徽中医药大学
Abstract—Due to the tumor heterogeneity and the diversity of the immune microenvironment, not all HCC patients could achieve the desired therapeutic effect from the immunotherapy. We identified three immune clusters with increasing ESTIMATE scores and redefined them as Cluster A (high immune), B (intermediate immune), and C (low immune) in HCC. Through the combination of the bulk and single-cell RNA-seq data, statistical differences of infiltrating immune cells, tumor mutational burden, and immune checkpoints were comprehensively explored to compare the diversity of immune microenvironment among clusters. Additionally, we constructed an immune risk model and validated its prognosis value for the survival prediction in HCC. This study identifies the specific subtypes through the tumor immune microenvironment and reflects the distinct tumor phenotype and detailed immune landscape in HCC. And it would provide new insights into immunotherapy and improve the clinical benefit for HCC treatment.

 
Important Date

  • Conference Date

    Nov 13

    2021

    to

    Nov 14

    2021

  • Sep 30 2021

    Contribution Submission Deadline

  • Nov 14 2021

    Registration deadline

Sponsored By
Medical Physics Branch of Chinese Society of Biomedical Engineering
IEEE Beijing Section
Life Electronics Society of Chinese Institute of Electronics
Organized By
Anhui Biomedical Engineering Society.
University of Science and Technology of China
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