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Introduction

各分子生物学、免疫学、肿瘤学、肝病科学专家:​

自噬是继凋亡之后,生命科学最热门的研究领域之一,近年来,自噬研究得到了飞速发展。已经有研究表明,细胞自噬与多种疾病和癌症的发生有关,基于自噬研究的抗癌药物研发也是当前的热门。

虽然,目前已经报告了很多因素能诱导细胞发生自噬,如饥饿、生长因子缺乏、微生物感染、细胞器损伤、蛋白质折叠错误或聚集、DNA损伤、放疗、化疗等等,但是这一过程的详细的信号转到通路和网络仍未完全阐明,这么多刺激信号如何传递的、哪些自噬蛋白接受信号、又有哪些自噬蛋白去执行等很多问题都还在等待进一步解答中。为促进自噬领域最新研究成果的传播,推动转化医学的发展,我们举办中国北京第一届自噬与肝病国际会议,将邀请国内外分子生物学、免疫学、肿瘤学、肝病科学等方面的知名专家、教授,针对当前备受关注的研究热点及问题开展研讨,为广大同行搭建一个相互沟通交流的平台。

  • 大会概况
    • 2017年11月9-10日(11月8日全天报到)
    • 400人
    • 地点:中国北京
    • 主题:促进自噬领域最新研究成果的传播,推动转化医学的发展

主办单位: 首都医科大学附属北京佑安医院,北京市肝病研究所(Capital Medical University, YouAnHospital, Beijing Institute of Hepatology)

会议主席 Chairs: 陈德喜 Dexi Chen,殷晓鸣(Xiao-Ming Yin )

November 8               全天注册registration

November 9

8:00-11:30           Morning session (上午会议)

Moderators (主持人):

Dexi Chen(陈德喜), Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都医科大学附属北京佑安医院,北京市肝病研究所)

James Ou, University of Southern California, USA

8:00-8:15             Ni Li (李宁)

首都医科大学附属北京佑安医院院长,北京市肝病研究所所长

Opening Remarks

(开幕词)

The Frontier of Autophagy Research-1(自噬研究前沿-1)

8:15-9: 00            John Lemasters

University of South Carolina, USA

Mitophagy: types, initiators and role in mitochondrial quality control

(线粒体自噬: 类型, 启动机制, 及在线粒体质控中的作用)

Theme 1. Role of Autophagy in Hepatic Homeostasis

(主题1.自噬在肝脏稳态平衡中的作用)

9:05-9:50             Dexi Chen (陈德喜)

Capital Medical University, YouAnHospital, Beijing Institute of Hepatology(首都医科大学附属北京佑安医院,北京市肝病研究所)

Autophagy and the liver diseases

(自噬和肝脏疾病)

9:55-10:40           Wen-Xing Ding (丁文兴)

University of Kansas Medical Center, Kansas City, Kansas, USA

TFEB-mediated lysosome biogenesis in acute-on-chronic alcohol-induced liver injury

(酒精性肝炎中TFEB介导的溶酶体生成机制)

10:45-11:30         Wei An (安威)

首都医科大学基础医学院

Mitophagy and liver regeneration

(线粒体自噬与肝再生)

11:30-1:30           Lunch Break

1:30-5:00             Afternoon session (下午会议)

Moderators (主持人):

Xiao-Ming Yin (殷晓鸣), Indiana University School of Medicine

Feng Ren (任锋), Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都医科大学附属北京佑安医院,北京市肝病研究所)

The Frontier of Autophagy Research-2(自噬研究前沿-2)

1:30-2:15             Li Yu (俞立)

清华大学生命科学学院

Mechanism of autophagic lysosome reformation

(自噬性溶酶体再生之机理)

Theme 2. Role of Autophagy in Liver Tumorigenesis

(主题2.自噬在肝癌发生中的作用)

2:20-3:05             Masaaki Komatsu

Niigata University, Japan

Autophagy-specific substrates, p62 and NBR1 serve as drive gene products in hepatocellular carcinoma

(自噬特异性底物p62 和NBR1是肝细胞癌的驱动性基因产物)

3:10-3:55             Huiguo Ding (丁慧国)

Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都医科大学附属北京佑安医院,北京市肝病研究所)

Hepatic stellar cells affect the autophagy of hepatocellular carcinoma cells by H2S and its molecular mechanism

(肝星状细胞通过H2S影响肝癌细胞自噬的分子机制)

4:00-4:45             James Ou

University of Southern California, USA

Autophagy and Hepatocarcinogenesis

(自噬和肝细胞癌的发生机制)

4:45-5:00             End of day discussion

November 10

8:00-11:30           Morning session (上午会议)

Moderators (主持人):

John Lemasters, University of South Carolina, USA

Huiguo Ding (丁慧国), Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都医科大学附属北京佑安医院,北京市肝病研究所)

The Frontier of Autophagy Research-3(自噬研究前沿-3)

8:15-9: 00            Eeva-LissaEskelina

University of Helsinki, Finland

Dissecting phagophore assembly site using 3D electron microscopy

(用3D电子显微镜术分析自噬膜前体形成的位置)

Theme 3. Role of Autophagy in Hepatic Viral Infection

(主题3.自噬在病毒性肝炎中的作用)

9:05-9:50             Zhengdong Zhao (赵振东)

中国医学科学院病原所

HCV and autophagy

(乙肝病毒和自噬)

9:55-10:40           Aleem Siddiqui

University of California at San Diego, USA

Mitochondrial dynamics, mitophagy and innate immunity in viral hepatitis

(病毒性肝炎中线粒体动态,线粒体自噬和天然免疫的关系)

10:45-11:30         Ying Shi (石英)

Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都医科大学附属北京佑安医院,北京市肝病研究所)

Apotentialstrategy to inhibit HBV replication through reducing hepatocytic autophagy

乙型肝炎病毒诱导的自噬及一种通过降低肝细胞自噬抑制HBV复制的新策略

11:30-1:30           LunchBreak

1:30-5:00             Afternoon session (下午会议)

Moderators (主持人):

Wen-Xing Ding (丁文兴), University of Kansas Medical Center, Kansas City, Kansas, USA

Ying Shi (石英), Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都医科大学附属北京佑安医院,北京市肝病研究所)

The Frontier of Autophagy Research-4(自噬研究前沿-4)

1:30-2:15             Xiao-Ming Yin (殷晓鸣)

Indiana University School of Medicine, USA

The homeostatic role of autophagy in preventing liver injury

(自噬在预防肝损伤中的稳态作用)

Theme 4.  Role of Autophagy in Liver Injury

(主题4.自噬在肝脏损伤中的作用)

2:20-3:05             Feng Ren (任锋)

Capital Medical University, YouAnHospital, Beijing Institute of Hepatology (首都医科大学附属北京佑安医院,北京市肝病研究所)

The Critical role of autophagy in the pathogenesis of liver failure and its molecular regulatory mechanisms

(自噬在肝衰竭病理中的关键作用及分子调节机理)

3:10-3:55             Yu Li (李于)

中国科学院营养研究所Finding a target for Berbering in the liver

(寻找小檗碱在肝脏中的靶点)

4:00-4:45             Xiuhui Li (李秀慧)

Capital Medical University, YouAnHostpical, Beijing Institute of Hepatology (首都医科大学附属北京佑安医院,北京市肝病研究所)

Role of autophagy in the prevention and treatment of acute liver injury by Chinese Medicine

(自噬在中医药防治急性肝损伤中的作用)

4:50-5:00             DexiChen(陈德喜)

Capital Medical University, YouAnHostpical, Beijing Institute of Hepatology (首都医科大学附属北京佑安医院,北京市肝病研究所)

Closing Remarks

(闭幕词)

因通知下发数量有限,各单位可以转发。凡参加培训班的同志,请认真填写下面的报名回执表,寄至:北京市100043-60分箱  邮  编:100043 

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    Nov 08

    2017

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    Nov 13

    2017

  • Nov 13 2017

    Registration deadline

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北京市肝病研究所
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