Presentation Details
Hexabromocyclododecane-induced reproductive toxicity in Brachionus plicatilis: Impacts and assessment
ID：558
View Protection：ATTENDEE
Updated Time：2024-10-12 13:44:26 Hits：749
Poster Presentation
Start Time：2025-01-16 18:05（Asia/Shanghai）
Duration：15min
Session：S51 Session 51-The Changing Coastal Environment: From Land-Sourced Pollution to Marine Ecological Risk »
No files
Abstract
Hexabromocyclododecane (HBCD), an emerging pollutant, has aroused worldwide concern because of its wide application and potentially negative impacts on marine ecosystems, but an information gap still exists regarding marine low-trophic organisms. Brachionus plicatilis, the model marine zooplankton, was used in the present study, and its reproductive responses were used as the endpoint to indicate HBCD-induced toxicity. HBCD was suggested to be extremely highly toxic compounds regarding the 96 h-LC50 of 0.58 mg L-1. The sublethal exposure of HBCD injured the reproduction of B. plicatilis: The total number of offspring per female and the key population index calculated from the life table, including the intrinsic rate of population increase (rm) and net reproductive rate (R0), were significantly influenced in a concentration-dependent manner. The reproductive process was also altered, as indicated by the first spawning time, first hatching time and oocyst development time. At the same time, individual survival and growth (body length) were also negatively affected by HBCD. Reactive oxygen species (ROS) were suggested to be responsible for reproductive toxicity mainly because the total ROS contents as well as the main components of •OH and H2O2 greatly increased and resulted in the oxidative imbalance that presented as malondialdehyde (MDA) elevation. Simultaneous activation of the glutathione antioxidant system was accompanied by the apoptosis marker enzymes Caspase-3 and 9, as well as the correlation between ROS content, physiological alteration and cell apoptosis, providing further evidence for this. The integrated biomarker response (IBR) and adverse outcome pathway (AOP) showed that HBCD had a significant toxic effect on B. plicatilis near the concentration range of 96 h-LC50. The establishment of this concentration range will provide a reliable reference for future environmental concentration warning of HBCD in marine.
Keywords
HBCD,Marine rotifer,Reactive oxygen species,Oxidative stress,Apoptosis,Risk assessment
Speaker
Na Lu
PhD Ocean University of ChinaSubmission Author
All Comments
Important Date
-
Conference Date
Jan 13
2025
toJan 17
2025
-
Sep 27 2024
Draft paper submission deadline
-
Feb 17 2025
Registration deadline
Sponsored By
State Key Laboratory of Marine Environmental Science, Xiamen University
Organized By
State Key Laboratory of Marine Environmental Science, Xiamen University
Department of Earth Sciences, National Natural Science Foundation of China
Department of Earth Sciences, National Natural Science Foundation of China
Contact Information
- Kejing GU
- xm******@xmu.edu.cn
- +86*********
Submit Comment